Loss of p53 Promotes Anaplasia and Local Invasion in ret/PTC1-Induced Thyroid Carcinomas

Papillary thyroid carcinomas in humans are associated with the ret/PTC oncogene and, following loss of p53 function, may progress to anaplastic carcinomas. Mice with thyroid-targeted expression of ret/PTC1 developed papillary thyroid carcinomas that were minimally invasive and did not metastasize. T...

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Autori principali: La Perle, Krista M. D., Jhiang, Sissy M., Capen, Charles C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2000
Soggetti:
Animal Models
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850128/
https://ncbi.nlm.nih.gov/pubmed/10934169
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