The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats

Squalene is a cholesterol precursor, which stimulates the immune system nonspecifically. We demonstrate that one intradermal injection of this adjuvant lipid can induce joint-specific inflammation in arthritis-prone DA rats. Histopathological and immunohistochemical analyses revealed erosion of bone...

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Bibliographic Details
Main Authors: Carlson, Barbro C., Jansson, Åsa M., Larsson, Anders, Bucht, Anders, Lorentzen, Johnny C.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850095/
https://ncbi.nlm.nih.gov/pubmed/10854227
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