Cyclin D2 Overexpression and Lack of p27 Correlate Positively and Cyclin E Inversely with a Poor Prognosis in Gastric Cancer Cases

G1 cyclins and cyclin-dependent kinase (CDK) complexes play important roles in G1 cell cycle transition, and their overexpression is implicated for neoplasia. The p27 protein (p27) negatively regulates G1 progression by binding to G1 cyclins/CDK complexes and inhibits their activity, resulting in in...

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Autors principals: Takano, Yasuo, Kato, Yo, van Diest, Paul J., Masuda, Mitsunobu, Mitomi, Hiroyuki, Okayasu, Isao
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2000
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850035/
https://ncbi.nlm.nih.gov/pubmed/10666388
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