OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

In obese Zucker diabetic fatty (ZDF) rats with mutant leptin receptors, pancreatic islets have an ≈50-fold increase in fat (TG), overproduce nitric oxide (NO), and lack a normal proinsulin mRNA response to fatty acids. We overexpressed the wild-type full-length “b” isoform of the leptin receptor (OB...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, May-Yun, Koyama, Kazunori, Shimabukuro, Michio, Newgard, Christopher B., Unger, Roger H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18486/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435258/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.2.714
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