OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

In obese Zucker diabetic fatty (ZDF) rats with mutant leptin receptors, pancreatic islets have an ≈50-fold increase in fat (TG), overproduce nitric oxide (NO), and lack a normal proinsulin mRNA response to fatty acids. We overexpressed the wild-type full-length “b” isoform of the leptin receptor (OB...

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Main Authors: Wang, May-Yun, Koyama, Kazunori, Shimabukuro, Michio, Newgard, Christopher B., Unger, Roger H.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18486/
https://ncbi.nlm.nih.gov/pubmed/9435258
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