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Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis

As a result of a chemical genetic screen for modulators of metalloprotease activity, we report that 2-mercaptopyridine-N-oxide induces a conspicuous undulating notochord defect in zebrafish embryos, a phenocopy of the leviathan mutant. The location of the chemically-induced wavy notochord correlated...

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Hlavní autoři: Anderson, Carrie, Bartlett, Stephen J., Gansner, John M., Wilson, Duncan, He, Ling, Gitlin, Jonathan D., Kelsh, Robert N., Dowden, James
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847539/
https://ncbi.nlm.nih.gov/pubmed/17216056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b613673g
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