Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk

Breast cancer risk is a polygenic trait. To identify breast cancer modifier alleles that have a high population frequency and low penetrance we used a comparative genomics approach. Quantitative trait loci (QTL) were initially identified by linkage analysis in a rat mammary carcinogenesis model foll...

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Bibliographic Details
Main Authors: Samuelson, David J., Hesselson, Stephanie E., Aperavich, Beth A., Zan, Yunhong, Haag, Jill D., Trentham-Dietz, Amy, Hampton, John M., Mau, Bob, Chen, Kai-Shun, Baynes, Caroline, Khaw, Kay-Tee, Luben, Robert, Perkins, Barbara, Shah, Mitul, Pharoah, Paul D., Dunning, Alison M., Easton, Doug F., Ponder, Bruce A., Gould, Michael N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847458/
https://ncbi.nlm.nih.gov/pubmed/17404222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701687104
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