Effect of 7 alpha substitution of cephems on their beta-lactamase stability and affinity for penicillin-binding proteins in Morganella morganii.
Cephamycins, which have a methoxy group at the 7 alpha position of their cephalosporin nuclei, were highly stable against hydrolysis by a beta-lactamase purified from a clinical isolate of Morganella morganii, whereas their 7 alpha-H analogs were rapidly hydrolyzed by the enzyme. The high stability...
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| 發表在: | Antimicrob Agents Chemother |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology (ASM)
1983
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC184692/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6602587/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.23.4.522 |
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