Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: Structure and stability of the per-thiaproline mutant of annexin V

Residue-specific bioincorporation of 1,3-thiazolidine-4-carboxylic acid [thiaproline, Pro(S)], a non-natural amino acid analog of proline, into human recombinant annexin V was achieved with a proline-auxotrophic Escherichia coli strain by fermentation procedures in minimal medium. Quantitative repla...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Budisa, Nediljko, Minks, Caroline, Medrano, F. Javier, Lutz, Jürgen, Huber, Robert, Moroder, Luis
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435213/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.2.455
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