Embryonic endocrine pancreas and mature β cells acquire α and PP cell phenotypes upon Arx misexpression

Aristaless-related homeobox (Arx) was recently demonstrated to be involved in pancreatic α cell fate specification while simultaneously repressing the β and δ cell lineages. To establish whether Arx is not only necessary, but also sufficient to instruct the α cell fate in endocrine progenitors, we u...

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Bibliografiska uppgifter
Huvudupphovsmän: Collombat, Patrick, Hecksher-Sørensen, Jacob, Krull, Jens, Berger, Joachim, Riedel, Dietmar, Herrera, Pedro L., Serup, Palle, Mansouri, Ahmed
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2007
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839241/
https://ncbi.nlm.nih.gov/pubmed/17404619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29115
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