Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons

BACKGROUND: Genomic comparisons between human and distant, non-primate mammals are commonly used to identify cis-regulatory elements based on constrained sequence evolution. However, these methods fail to detect functional elements that are too weakly conserved among mammals to distinguish them from...

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Main Authors: Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M, Boffelli, Dario
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839124/
https://ncbi.nlm.nih.gov/pubmed/17201929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-1-r1
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