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Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development

Ewing sarcoma gene EWS encodes a putative RNA-binding protein with proposed roles in transcription and splicing, but its physiological role in vivo remains undefined. Here, we have generated Ews-deficient mice and demonstrated that EWS is required for the completion of B cell development and meiosis...

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Detalhes bibliográficos
Main Authors: Li, Hongjie, Watford, Wendy, Li, Cuiling, Parmelee, Alissa, Bryant, Mark A., Deng, Chuxia, O’Shea, John, Lee, Sean Bong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838927/
https://ncbi.nlm.nih.gov/pubmed/17415412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31222
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