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Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism

Taxol (Paclitaxel) is an important natural product for the treatment of solid tumors. Despite a well documented tubulin-stabilizing effect, many side effects of taxol therapy cannot be explained by cytoskeletal mechanisms. In the present study submicromolar concentrations of taxol, mimicking concent...

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Detalhes bibliográficos
Main Authors: Boehmerle, Wolfgang, Splittgerber, Ute, Lazarus, Michael B., McKenzie, Kathleen M., Johnston, David G., Austin, David J., Ehrlich, Barbara E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838755/
https://ncbi.nlm.nih.gov/pubmed/17114292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607240103
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