Transgenic LacZ under control of Hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules

Hec-6st is a highly specific high endothelial venule (HEV) gene that is crucial for regulating lymphocyte homing to lymph nodes (LN). The enzyme is also expressed in HEV-like vessels in tertiary lymphoid organs that form in chronic inflammation in autoimmunity, graft rejection, and microbial infecti...

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Bibliographic Details
Main Authors: Liao, Shan, Bentley, Kevin, Lebrun, Marielle, Lesslauer, Werner, Ruddle, Frank H., Ruddle, Nancy H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838643/
https://ncbi.nlm.nih.gov/pubmed/17360566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700334104
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