Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics

The genetic factors contributing to the complex disorder of myocardial calcification are largely unknown. Using a mouse model, we fine-mapped the major locus (Dyscalc1) contributing to the dystrophic cardiac calcification (DCC) to an 840-kb interval containing 38 genes. We then identified the causal...

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Détails bibliographiques
Auteurs principaux: Meng, Haijin, Vera, Iset, Che, Nam, Wang, Xuping, Wang, Susanna S., Ingram-Drake, Leslie, Schadt, Eric E., Drake, Thomas A., Lusis, Aldons J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838635/
https://ncbi.nlm.nih.gov/pubmed/17360558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607620104
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