Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction

RING-finger proteins commonly function as ubiquitin ligases that mediate protein degradation by the ubiquitin-proteasome pathway. Muscle-specific RING-finger (MuRF) proteins are striated muscle-restricted components of the sarcomere that are thought to possess ubiquitin ligase activity. We show that...

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Main Authors: Fielitz, Jens, van Rooij, Eva, Spencer, Jeffrey A., Shelton, John M., Latif, Shuaib, van der Nagel, Roel, Bezprozvannaya, Svetlana, de Windt, Leon, Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838610/
https://ncbi.nlm.nih.gov/pubmed/17360532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611726104
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