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Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation
BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase (PI3K)/Akt and MAPK/ERK pathways. However, the rol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838569/ https://ncbi.nlm.nih.gov/pubmed/17406664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000340 |
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