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Decline in ribosomal fidelity contributes to the accumulation and stabilization of the master stress response regulator σ(S) upon carbon starvation

The σ(S) subunit of RNA polymerase is a master regulator of Escherichia coli that retards cellular senescence and bestows cells with general stress protective functions during growth arrest. We show that mutations and drugs triggering translational errors elevate σ(S) levels and stability. Furthermo...

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Bibliografiske detaljer
Main Authors: Fredriksson, Åsa, Ballesteros, Manuel, Peterson, Celeste N., Persson, Örjan, Silhavy, Thomas J., Nyström, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838536/
https://ncbi.nlm.nih.gov/pubmed/17403784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.409407
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