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Chronic depolarization enhances the trophic effects of BDNF in rescuing auditory neurons following a sensorineural hearing loss

The development and maintenance of spiral ganglion neurons (SGNs) appears to be supported by both neural activity and neurotrophins. Removal of this support leads to their gradual degeneration. Here, we examine whether the exogenous delivery of the neurotrophin brain-derived neurotrophic factor (BDN...

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Hlavní autoři: Shepherd, Robert K., Coco, Anne, Epp, Stephanie B., Crook, Jeremy M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831822/
https://ncbi.nlm.nih.gov/pubmed/15844207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.20564
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