EVIDENCE OF EXTRA-TELOMERIC EFFECTS OF hTERT AND ITS REGULATION INVOLVING A FEEDBACK LOOP(*)

The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase which is responsible for telomeric maintenance and extension. Using RNA interference to knock down hTERT mRNA expression, we provide evidence that hTERT exerts extra-telomeric effects on the cell cyc...

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Bibliografiske detaljer
Main Authors: Lai, Serene R., Cunningham, Amanda P., Huynh, Vu Q., Andrews, Lucy G., Tollefsbol, Trygve O.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829489/
https://ncbi.nlm.nih.gov/pubmed/17134697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2006.10.014
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