EVIDENCE OF EXTRA-TELOMERIC EFFECTS OF hTERT AND ITS REGULATION INVOLVING A FEEDBACK LOOP(*)

The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase which is responsible for telomeric maintenance and extension. Using RNA interference to knock down hTERT mRNA expression, we provide evidence that hTERT exerts extra-telomeric effects on the cell cyc...

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Hlavní autoři: Lai, Serene R., Cunningham, Amanda P., Huynh, Vu Q., Andrews, Lucy G., Tollefsbol, Trygve O.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829489/
https://ncbi.nlm.nih.gov/pubmed/17134697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2006.10.014
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