Sustained formation of POBN radical adducts in mouse liver by peroxisome proliferators is dependent upon PPARα, but not NADPH oxidase

Reactive oxygen species are thought to be crucial for peroxisome proliferator-induced liver carcinogenesis. Free radicals have been shown to mediate the production of mitogenic cytokines by Kupffer cells and cause DNA damage in rodent liver. Previous in vivo experiments demonstrated that acute admin...

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Main Authors: Woods, Courtney G., Burns, Amanda M., Maki, Akira, Bradford, Blair U., Cunningham, Michael L., Connor, Henry D., Kadiiska, Maria B., Mason, Ronald P., Peters, Jeffrey M., Rusyn, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829322/
https://ncbi.nlm.nih.gov/pubmed/17210446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.10.053
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