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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors (GPCRs) that are activated solely by a pharmacologically inert drug-like and bioavailable compound (clozapine-N-oxide). Subsequent screening in human cell lines facilitated the creation of a family of muscar...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1829280/ https://ncbi.nlm.nih.gov/pubmed/17360345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700293104 |
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