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Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin

Pasteurella multocida toxin (PMT), one of the virulence factors produced by the bacteria, exerts its toxicity by up-regulating various signaling cascades downstream of the heterotrimeric GTPases Gq and G12/13 in an unknown fashion. Here, we present the crystal structure of the C-terminal region (res...

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Detalhes bibliográficos
Main Authors: Kitadokoro, Kengo, Kamitani, Shigeki, Miyazawa, Masayuki, Hanajima-Ozawa, Miyuki, Fukui, Aya, Miyake, Masami, Horiguchi, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829276/
https://ncbi.nlm.nih.gov/pubmed/17360394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608197104
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