The Iron-Sulfur Cluster Proteins Isa1 and Isa2 Are Required for the Function but Not for the De Novo Synthesis of the Fe/S Clusters of Biotin Synthase in Saccharomyces cerevisiae

The yeast Saccharomyces cerevisiae is able to use some biotin precursors for biotin biosynthesis. Insertion of a sulfur atom into desthiobiotin, the final step in the biosynthetic pathway, is catalyzed by biotin synthase (Bio2). This mitochondrial protein contains two iron-sulfur (Fe/S) clusters tha...

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Hauptverfasser: Mühlenhoff, Ulrich, Gerl, Mathias J., Flauger, Birgit, Pirner, Heike M., Balser, Sandra, Richhardt, Nadine, Lill, Roland, Stolz, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828929/
https://ncbi.nlm.nih.gov/pubmed/17259550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00191-06
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