DNA Vaccine Construct Incorporating Intercellular Trafficking and Intracellular Targeting Motifs Effectively Primes and Induces Memory B- and T-Cell Responses in Outbred Animals

We developed a vaccine construct in which a BVP22 domain and an invariant-chain major histocompatibility complex class II-targeting motif capable of enhancing dendritic cell antigen uptake and presentation were fused to a sequence encoding a B- and T-cell antigen from the Anaplasma marginale major s...

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Bibliographische Detailangaben
Hauptverfasser: Mwangi, Waithaka, Brown, Wendy C., Splitter, Gary A., Davies, Christopher J., Howard, Chris J., Hope, Jayne C., Aida, Yoko, Zhuang, Yan, Hunter, Beverly J., Palmer, Guy H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Vaccine Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828862/
https://ncbi.nlm.nih.gov/pubmed/17215335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00363-06
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