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Characterization of a Large, Stable, High-Copy-Number Streptomyces Plasmid That Requires Stability and Transfer Functions for Heterologous Polyketide Overproduction

A major limitation to improving small-molecule pharmaceutical production in streptomycetes is the inability of high-copy-number plasmids to tolerate large biosynthetic gene cluster inserts. A recent finding has overcome this barrier. In 2003, Hu et al. discovered a stable, high-copy-number, 81-kb pl...

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主要な著者: Fong, Ryan, Hu, Zhihao, Hutchinson, C. Richard, Huang, Jianqiang, Cohen, Stanley, Kao, Camilla
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828658/
https://ncbi.nlm.nih.gov/pubmed/17142363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01888-06
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