Comparison of the inhibitory effects of interferon alfacon-1 and ribavirin on yellow fever virus infection in a hamster model

Antiviral compounds were evaluated for efficacy against yellow fever virus (YFV) in a hamster model of YFV-induced liver disease. Challenge with a 10(2) 50% cell culture infectious doses of YFV resulted in a 50–80% mortality rate in female hamsters. Virus was detected by QRT-PCR in liver, kidney, sp...

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Bibliographic Details
Main Authors: Julander, Justin G., Morrey, John D., Blatt, Lawrence M., Schafer, Kristiina, Sidwell, Robert W.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828627/
https://ncbi.nlm.nih.gov/pubmed/17049380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2006.08.008
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