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Role of Complement in Defense of the Middle Ear Revealed by Restoring the Virulence of Nontypeable Haemophilus influenzae siaB Mutants

Nontypeable (NT) Haemophilus influenzae is an important cause of otitis media in children. We have shown previously that NT H. influenzae mutants defective in their ability to sialylate lipopolysaccharide (LPS), called siaB mutants, show attenuated virulence in a chinchilla model of experimental oti...

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Autors principals: Figueira, Marisol A., Ram, Sanjay, Goldstein, Richard, Hood, Derek W., Moxon, E. Richard, Pelton, Stephen I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828410/
https://ncbi.nlm.nih.gov/pubmed/17088344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01054-06
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