Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection

BACKGROUND: CD8+ T cells impact control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. In HIV-1 infection, persistent HIV-1 specific IFN-γ+ CD8+ T cell responses are detected in the setting of disease progression, consistent with functional...

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Auteurs principaux: Addo, Marylyn M., Draenert, Rika, Rathod, Almas, Verrill, Cori L., Davis, Benjamin T., Gandhi, Rajesh T., Robbins, Gregory K., Basgoz, Nesli O., Stone, David R., Cohen, Daniel E., Johnston, Mary N., Flynn, Theresa, Wurcel, Alysse G., Rosenberg, Eric S., Altfeld, Marcus, Walker, Bruce D.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2007
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1824710/
https://ncbi.nlm.nih.gov/pubmed/17389912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000321
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