Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation

The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound to ANTXR1, but only at pH ∼5.0 or below when it is bound to ANTXR2. Here, stru...

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Detaylı Bibliyografya
Asıl Yazarlar: Scobie, Heather M., Marlett, John M., Rainey, G. Jonah A., Lacy, D. Borden, Collier, R. John, Young, John A.T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2007
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1824706/
https://ncbi.nlm.nih.gov/pubmed/17389920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000329
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