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Factor analysis for gene regulatory networks and transcription factor activity profiles

BACKGROUND: Most existing algorithms for the inference of the structure of gene regulatory networks from gene expression data assume that the activity levels of transcription factors (TFs) are proportional to their mRNA levels. This assumption is invalid for most biological systems. However, one mig...

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Main Authors: Pournara, Iosifina, Wernisch, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821042/
https://ncbi.nlm.nih.gov/pubmed/17319944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-8-61
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