Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay

Many alternative splicing events create RNAs with premature stop codons, suggesting that alternative splicing coupled with nonsense-mediated decay (AS-NMD) may regulate gene expression post-transcriptionally. We tested this idea in mice by blocking NMD and measuring changes in isoform representation...

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Autors principals: Ni, Julie Z., Grate, Leslie, Donohue, John Paul, Preston, Christine, Nobida, Naomi, O’Brien, Georgeann, Shiue, Lily, Clark, Tyson A., Blume, John E., Ares, Manuel
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2007
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820944/
https://ncbi.nlm.nih.gov/pubmed/17369403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1525507
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