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Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes

The repressive activity of histone deacetylase 7 (HDAC7), a class IIa HDAC expressed in CD4(+)CD8(+) double-positive thymocytes, is regulated by its nucleocytoplasmic shuttling. In resting thymocytes, HDAC7 is nuclear and functions as a transcriptional repressor. After T-cell receptor (TCR) activati...

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Detalhes bibliográficos
Main Authors: Parra, Maribel, Mahmoudi, Tokameh, Verdin, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820937/
https://ncbi.nlm.nih.gov/pubmed/17369396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1513107
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