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Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes
The repressive activity of histone deacetylase 7 (HDAC7), a class IIa HDAC expressed in CD4(+)CD8(+) double-positive thymocytes, is regulated by its nucleocytoplasmic shuttling. In resting thymocytes, HDAC7 is nuclear and functions as a transcriptional repressor. After T-cell receptor (TCR) activati...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820937/ https://ncbi.nlm.nih.gov/pubmed/17369396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1513107 |
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