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Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bodm...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820699/ https://ncbi.nlm.nih.gov/pubmed/17360468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611179104 |
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