In vitro antagonism of beta-lactam antibiotics by cefoxitin.

We assessed the extent and mechanisms of antagonism of beta-lactam antibiotics by cefoxitin. In tests with 41 gram-negative isolates, cefoxitin antagonized cephalothin, cefamandole, cefsulodin, cefotaxime, moxalactam, ampicillin, carbenicillin, piperacillin, mezlocillin, and azlocillin, but not ceph...

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Main Authors: Sanders, C C, Sanders, W E, Goering, R V
Formato: Artigo
Idioma:Inglês
Publicado em: 1982
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC182054/
https://ncbi.nlm.nih.gov/pubmed/6981376
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spelling pubmed-1820542003-12-16 In vitro antagonism of beta-lactam antibiotics by cefoxitin. Sanders, C C Sanders, W E Goering, R V Antimicrob Agents Chemother Research Article We assessed the extent and mechanisms of antagonism of beta-lactam antibiotics by cefoxitin. In tests with 41 gram-negative isolates, cefoxitin antagonized cephalothin, cefamandole, cefsulodin, cefotaxime, moxalactam, ampicillin, carbenicillin, piperacillin, mezlocillin, and azlocillin, but not cephalexin, mecillinam, or N-formimidoyl thienamycin. The extent of antagonism varied with the beta-lactam and genus studied. However, antagonism occurred most often with strains possessing inducible cephalosporinases. Antagonism of cephalothin and cefamandole correlated closely with the induction of beta-lactamases capable of inactivating these drugs. Although antagonism of the remaining drugs occurred more often with strains possessing inducible beta-lactamases, these enzymes did not inactivate the drugs. Morphological studies revealed that cefoxitin inhibited filamentation and lysis produced by various beta-lactam drugs. Results of this investigation suggest that cefoxitin antagonizes beta-lactams via (i) induction of drug-inactivating beta-lactamases, and (ii) the induction of beta-lactamases that cannot inactivate the drug but serve as barriers against access to target proteins. This barrier appears most efficient for drugs that bind to penicillin-binding proteins 1 and 3. 1982-06 /pmc/articles/PMC182054/ /pubmed/6981376 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Research Article
spellingShingle Research Article
Sanders, C C
Sanders, W E
Goering, R V
In vitro antagonism of beta-lactam antibiotics by cefoxitin.
description We assessed the extent and mechanisms of antagonism of beta-lactam antibiotics by cefoxitin. In tests with 41 gram-negative isolates, cefoxitin antagonized cephalothin, cefamandole, cefsulodin, cefotaxime, moxalactam, ampicillin, carbenicillin, piperacillin, mezlocillin, and azlocillin, but not cephalexin, mecillinam, or N-formimidoyl thienamycin. The extent of antagonism varied with the beta-lactam and genus studied. However, antagonism occurred most often with strains possessing inducible cephalosporinases. Antagonism of cephalothin and cefamandole correlated closely with the induction of beta-lactamases capable of inactivating these drugs. Although antagonism of the remaining drugs occurred more often with strains possessing inducible beta-lactamases, these enzymes did not inactivate the drugs. Morphological studies revealed that cefoxitin inhibited filamentation and lysis produced by various beta-lactam drugs. Results of this investigation suggest that cefoxitin antagonizes beta-lactams via (i) induction of drug-inactivating beta-lactamases, and (ii) the induction of beta-lactamases that cannot inactivate the drug but serve as barriers against access to target proteins. This barrier appears most efficient for drugs that bind to penicillin-binding proteins 1 and 3.
author Sanders, C C
Sanders, W E
Goering, R V
author_facet Sanders, C C
Sanders, W E
Goering, R V
author_sort Sanders, C C
title In vitro antagonism of beta-lactam antibiotics by cefoxitin.
title_short In vitro antagonism of beta-lactam antibiotics by cefoxitin.
title_full In vitro antagonism of beta-lactam antibiotics by cefoxitin.
title_fullStr In vitro antagonism of beta-lactam antibiotics by cefoxitin.
title_full_unstemmed In vitro antagonism of beta-lactam antibiotics by cefoxitin.
title_sort in vitro antagonism of beta-lactam antibiotics by cefoxitin.
publishDate 1982
url https://ncbi.nlm.nih.gov/pmc/articles/PMC182054/
https://ncbi.nlm.nih.gov/pubmed/6981376
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