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Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons

Our previous studies found that nerve growth factor (NGF), via ceramide, enhanced the number of action potentials (APs) evoked by a ramp of depolarizing current in capsaicin-sensitive sensory neurons. Ceramide can be metabolized by ceramidase to sphingosine (Sph), and Sph to sphingosine 1-phosphate...

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Bibliografski detalji
Glavni autori: Zhang, Y H, Vasko, M R, Nicol, G D
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1819432/
https://ncbi.nlm.nih.gov/pubmed/16740613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.111575
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