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Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold protein confer resistance to rifampicin
D13 protein trimers, which form an external lattice providing curvature to the membrane of vaccinia virus immature virions, are the target of the drug rifampicin. We obtained 63 rifampicin-resistant mutants following random PCR mutagenesis of the D13L gene and 5 that arose spontaneously. Sequencing...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1817899/ https://ncbi.nlm.nih.gov/pubmed/17055024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.09.031 |
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