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Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection
The analysis of molecular signatures of antigen-driven affinity selection of B cells is of immense use in studies on normal and abnormal B cell development. Most of the published literature compares the expected and observed frequencies of replacement (R) and silent (S) mutations in the complementar...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1817819/ https://ncbi.nlm.nih.gov/pubmed/16162266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2005.02208.x |
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