Human pharmacokinetics and disposition of sarmoxicillin, a lipophilic amoxicillin prodrug.

Sarmoxicillin, an amoxicillin prodrug, is the methoxymethyl ester of hetamoxicillin. Esterification converted amoxicillin from an amphoteric to a cationic compound and resulted in a 30- to 600-fold increase in lipid partitioning. Oral absorption studies in normal subjects demonstrated that sarmoxici...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Smyth, R D, Pfeffer, M, Van Harken, D R, Cohen, A, Hottendorf, G H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1981
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7271269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.19.6.1004
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