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Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-inducible gbp2 gene
A subgroup of genes induced by IFN-γ requires both STAT1 and IRF1 for transcriptional activation. Using WT, stat1(−/−), or irf1(−/−) cells, we analyzed the changes induced by IFN-γ in gbp2 promoter chromatin. STAT1 associated with the promoter independently of IRF1 and played an essential role in th...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1815270/ https://ncbi.nlm.nih.gov/pubmed/17293456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610944104 |
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