Treatment of autoimmune diseases in MRL/lpr mice by allogenic bone marrow transplantation plus adult thymus transplantation

MRL/lpr mice (H-2(k)) with Fas gene mutation develop severe autoimmune diseases, and their haematolymphoid cells such as bone marrow and spleen cells showed a low apoptotic activity by irradiation. Therefore, conventional bone marrow transplantation (BMT) cannot be used to treat autoimmune diseases...

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Main Authors: Hosaka, N, Ryu, T, Miyake, T, Cui, W, Nishida, T, Takaki, T, Inaba, M, Ikehara, S
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2007
Teme:
Animal Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810495/
https://ncbi.nlm.nih.gov/pubmed/17302907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2006.03310.x
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