The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees

BACKGROUND: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are excluded from the computation, significant power may be lost. Therefore accurate approximate methods which take into account...

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Bibliographic Details
Main Authors: Albers, Cornelis A, Leisink, Martijn AR, Kappen, Hilbert J
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Proceedings
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810310/
https://ncbi.nlm.nih.gov/pubmed/16723002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-7-S1-S1
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