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Extracellular Signal-Regulated Kinase 7, a Regulator of Hormone-Dependent Estrogen Receptor Destruction

Estrogen receptor alpha (ERα) degradation is regulated by ubiquitination, but the signaling pathways that modulate ERα turnover are unknown. We found that extracellular signal-regulated kinase 7 (ERK7) preferentially enhances the destruction of ERα but not the related androgen receptor. Loss of ERK7...

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Detalhes bibliográficos
Main Authors: Henrich, Lorin M., Smith, Jeffrey A., Kitt, Danielle, Errington, Timothy M., Nguyen, Binh, Traish, Abdulmaged M., Lannigan, Deborah A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC180983/
https://ncbi.nlm.nih.gov/pubmed/12917323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.5979-5988.2003
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