TSH receptor-adenovirus-induced Graves' hyperthyroidism is attenuated in both interferon-γ and interleukin-4 knockout mice; implications for the Th1/Th2 paradigm

The role of the Th1/Th2 balance in the pathogenesis of murine Graves' hyperthyroidism is controversial. In BALB/c mice injected with adenovirus expressing TSH receptor (TSHR-adeno model), we found that suppression of TSHR-specific Th1 immune responses by exogenous interleukin-4 (IL-4), α-galact...

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Detalhes bibliográficos
Main Authors: NAGAYAMA, Y, SAITOH, O, MCLACHLAN, S M, RAPOPORT, B, KANO, H, KUMAZAWA, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Animal Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809247/
https://ncbi.nlm.nih.gov/pubmed/15544617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02641.x
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