IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients

Activation of T cells requires both TCR-specific ligation and costimulation through accessory molecules during T cell priming. IFNγ is a key cytokine responsible for macrophage activation during Mycobacterium tuberculosis (Mtb) infection while IL-10 is associated with suppression of cell mediated im...

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Detalhes bibliográficos
Main Authors: DE LA BARRERA, S, ALEMÁN, M, MUSELLA, R, SCHIERLOH, P, PASQUINELLI, V, GARCÍA, V, ABBATE, E, SASIAIN, M DEL C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Clinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809183/
https://ncbi.nlm.nih.gov/pubmed/15373915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02577.x
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