Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1 gene. A conditional mouse model was developed to evaluate the loss of the mouse homolog, Men1, in th...

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Bibliographic Details
Main Authors: Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, Hager, Jeffrey H., Hanahan, Douglas, Edlund, Helena, Magnuson, Mark A., Garrett-Beal, Lisa, Burns, A. Lee, Ried, Thomas, Chandrasekharappa, Settara C., Marx, Stephen J., Spiegel, Allen M., Collins, Francis S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC180910/
https://ncbi.nlm.nih.gov/pubmed/12917331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.6075-6085.2003
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