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The candidate gene approach: have murine models informed the study of human SLE?

Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin-pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic he...

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Bibliografiske detaljer
Main Authors: CUNNINGHAME GRAHAM, D S, VYSE, T J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809082/
https://ncbi.nlm.nih.gov/pubmed/15196236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02525.x
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