Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice

Loss of deoxyribonuclease I (Dnase1) function is associated with systemic lupus erythematosus (SLE) in humans and mice; however, no coding mutations in Dnase1 are found in polygenic murine models. Instead, both MRL-lpr strains and NZB/W F1 hybrids are homozygous for T89I missense in the macrophage-D...

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Detalhes bibliográficos
Main Authors: WILBER, A, O'CONNOR, T P, LU, M L, KARIMI, A, SCHNEIDER, M C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Animal Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808827/
https://ncbi.nlm.nih.gov/pubmed/12974753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2003.02267.x
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