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Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum.

The antifungal activity of UK 49,858, a difluorophenyl bis-triazole derivative, was evaluated in vitro against seven strains of Histoplasma capsulatum and in vivo in AKR and C57BL/6 murine models of histoplasmosis. UK 49,858 had a lower toxicity for AKR and C57BL/6 mice than amphotericin B did. The...

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Autores principales: Kobayashi, G S, Travis, S, Medoff, G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1986
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC180462/
https://ncbi.nlm.nih.gov/pubmed/3010852
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