Novobiocin antagonism of amastigotes of Trypanosoma cruzi growing in cell-free medium.

Inhibitors of the enzyme bacterial topoisomerase II (DNA gyrase) were evaluated for activity against Trypanosoma cruzi (Brazil strain), based on the theoretical need for a topoisomerase II in the replication of the kinetoplast DNA network. Novobiocin (500 micrograms/ml) antagonized amastigotes of T....

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Pate, P G, Wolfson, J S, McHugh, G L, Pan, S C, Swartz, M N
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1986
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180408/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3521485/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.3.426
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