Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases

Nonspecific endonucleases hydrolyze DNA without sequence specificity but with sequence preference, however the structural basis for cleavage preference remains elusive. We show here that the nonspecific endonuclease ColE7 cleaves DNA with a preference for making nicks after (at 3′O-side) thymine bas...

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Bibliografiske detaljer
Main Authors: Wang, Yi-Ting, Yang, Wei-Jen, Li, Chia-Lung, Doudeva, Lyudmila G., Yuan, Hanna S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802626/
https://ncbi.nlm.nih.gov/pubmed/17175542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl621
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